What Happens When You Stop Taking a GLP-1
Most people regain a large share of the weight after stopping. What the withdrawal trials show, why it happens, and how to plan the off-ramp instead of pretending it does not exist.
Blog / Weight Loss
Weight Loss
Medically supervised GLP-1 protocols, what to expect month by month, and how to protect muscle while you lose fat. Evidence-based weight loss guidance from Defiant Health.
Why Weight Won't Budge in Perimenopause
Midlife weight gain is hormonal, not willpower. How declining estrogen changes your metabolism, and how medically supervised GLP-1 protocols may help while protecting muscle.
What to Expect Your First Month on a GLP-1
A week-by-week guide to starting semaglutide or tirzepatide: starter doses, appetite changes, side effects, and when your dose moves up.
Best Peptides for Weight Loss: What Actually Works
The peptides that drive weight loss are the GLP-1 class. Here is what the research shows, and what sermorelin, tesamorelin, and the other peptides actually do.
How to Protect Muscle Mass on a GLP-1
Up to 40% of weight lost on a GLP-1 can come from lean mass. The protein, training, and tracking protocol Defiant uses to protect what you've built.
Tirzepatide vs Semaglutide for Weight Loss: A Plain-English Comparison
Mechanism, trial results, side effects, cost, and how we decide between them at Defiant. Custom GLP-1 protocols from $295/mo.